Anti-ulcer Effect of Gastroretentive Drug Delivery System of Alginate Beads Containing Turmeric Extract Solid Dispersion
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Anti-Tumor Effect of a Local Delivery System; Hydroxyapatite-Alginate Beads of Paclitaxel
This study was conducted to clarify direct antitumor effect of this local delivery system of paclitaxel. Rat’s breast cancer cell line (CRL-1666) and Fischer 344 rat were used. When subcutaneous tumor (injected subcutaneously) size reached 10 mm in diameter, animals in the local treatment group were administered locally at dose of 5 mg/kg of paclitaxel-loaded HAp-alginate beads. Sham operation ...
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Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Drug absorption in the gastrointestinal tract is a highly variable procedure and prolonging gastric retention of the dosage form extends the time for drug absorption. Gastro retentive drug delivery system is one of such novel approaches to ...
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Oral delivery of drugs is by far the most preferable route of drug delivery . Oral-rate controlled drug delivery systems have an important area among novel drug delivery system. But these oral sustained release drug delivery systems suffer greatly due to their short gastric residence time/ gastric emptying time. Whereas prolonged gastric residence increases duration of drug release, reduces dru...
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A multiple-unit floating drug delivery system based on gas formation technique was developed, in order to prolong the gastric residence time and to increase the overall bioavailability of the dosage form. The floating bead formulations were prepared by dispersing nevirapine together with calcium carbonate in a mixture of sodium alginate and hydroxypropyl methylcellulose solution and then drippi...
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Sustained release gastroretentive dosage forms enable prolonged and continuous input of the drug to the upper parts of the gastrointestinal (GI) tract and improve the bioavailability of medications that are characterized by a narrow absorption window. A new strategy is proposed for the development of gastroretentive dosage forms for ofloxacin preferably once daily. The design of the delivery sy...
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ژورنال
عنوان ژورنال: Open Access Macedonian Journal of Medical Sciences
سال: 2021
ISSN: 1857-9655
DOI: 10.3889/oamjms.2021.5475